منابع مشابه
Studies on the Chronic Toxicity of Chloroquine
Ch lo roqu ine, 7-chloro-4(4-diethylamino-lmethylbutylamino) quinoline, is an antimalarial drug of the 4-amino quinoline series. It has been shown to have antimalarial activity similar to and superior to that of quinacrine in avian malaria, and in trophozoiteand sporozoite-induced vivax and falciparum malaria in man ( 1, 2, 3, 4). The present study was undertaken for the purpose of establishing...
متن کاملChronic Rat and Dog Toxicity Studies on Tartrazine.
Rats. Five groups of 24 Osborne-Mendel weanling rats, evenly divided by sex, were fed 5.0, 2.0, 1.0, 0.5, and 0.0% tartrazinemixed in their Purina laboratory chow diet for 2 years. Growth effect was negligible, and there was no effect on survival, hematology, or organ weights. The rats evidenced diarrhea at the 5% dosage level, slight diarrhea at the 2% level, and no diarrhea at the 1% level. T...
متن کاملChronic toxicity and reproduction studies of hexachlorobutadiene in rats
Hexachlorobutadiene (HCBD), while not produced commercially in the United States, may be encountered as an unwanted by-product of certain processes associated with the chlorination of hydrocarbons. Studies were conducted to assess the potential long-term toxicity of HCBD. In a reproduction study conducted in rats, dose levels of 20 or 2.0 mg/kg-day of HCBD induced slight maternal toxicity (prim...
متن کاملSub chronic toxicity studies of lactulose in rats.
Lactulose has profound health benefits by way of increasing bifidobacterial flora in the intestine of infants thereby protecting them against enteric infection, constipation and systemic encephalopathy. In the present study to assess the sub chronic toxicity of lactulose syrup, the rats were fed on a basal feed supplemented with lactulose syrup at 0.5, 1.0, 2.0 and 5.0% for a period of 21 weeks...
متن کاملStudies on the intracerebral toxicity of ammonia.
Interference with cerebral energy metabolism due to excess ammonia has been postulated as a cause of hepatic encephalopathy. Furthermore, consideration of the neurologic basis of such features of hepatic encephalopathy as asterixis, decerebrate rigidity, hyperpnea, and coma suggests a malfunction of structures in the base of the brain and their cortical connections. The three major sources of i...
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ژورنال
عنوان ژورنال: Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
سال: 1960
ISSN: 0015-6426,1882-1006
DOI: 10.3358/shokueishi.1.62